Estudo da ESTeSC-IPC aponta pistas sobre a evolução da doença de Alzheimer
No Politécnico de Coimbra um investigação realizada pelo docente António Gabriel, da Escola Superior de Tecnologia da Saúde do Politécnico de Coimbra, conclui que a combinação de dois genótipos (ApoE ε4 e a variante K da Butiricolinesterase) poderá ser importante na avaliação de risco de progressão da Doença de Alzheimer.
Professor António Gabriel. Imagem cedida pelo IPC
A investigação foi realizada em simultâneo com a comunidade docente da ESTeSC-IPC e o objetivo reside na clarificação do envolvimento das colinesterases na Doença de Alzheimer (DA). Participaram cerca de 600 indivíduos no estudo: 217 com DA, 70 com Demência Fronto Temporal, 200 controlos e 96 com Defeito Cognitivo Ligeiro (DCL).
A investigação realizada pelo docente António Gabriel, da Escola Superior de Tecnologia da Saúde do Politécnico de Coimbra, conclui que a combinação de dois genótipos (ApoE ε4 e a variante K da Butiricolinesterase) poderá ser importante na avaliação de risco de progressão da Doença de Alzheimer. A investigação foi realizada em simultâneo com a comunidade docente da ESTeSC-IPC e o objetivo reside na clarificação do envolvimento das colinesterases na Doença de Alzheimer (DA).
Com base na tese de doutoramento em Biociências sobre a “avaliação do sistema colinérgico na doença de Alzheimer” – lançada em livro pela ESTeSC-IPC no passado dia 7 de junho – o professor António Gabriel clarifica a presença da variante K da Butiricolinesterase, uma enzima com importância no sistema colinérgico. O efeito de sinergia entre esta variante e o gene alelo ApoE- ε4 contribui para “um aumento da incidência e redução do tempo de progressão de Defeito Cognitivo Ligeiro para Doença Símbolo de Memória Carolina Barreiros de Alzheimer”.
Mais Superior 2022@ Site desenvolvido por SITEIRIA
Nós e os nossos parceiros utilizamos determinadas tecnologias no nosso site, como os cookies, para personalizarmos os conteúdos e a publicidade, proporcionarmos funcionalidades das redes sociais e analisarmos o nosso tráfego. Clique em baixo para consentir a utilização destas tecnologias na web. Pode mudar de ideias e alterar as suas opções de consentimento em qualquer momento voltando a este site.
Aceitar
Opções
Configurações da caixa de cookies
Configurações da caixa de cookies
Privacy settings
Decide which cookies you want to allow.
You can change these settings at any time. However, this can result in some functions no longer being available. For information on deleting the cookies, please consult your browser’s help function.
Learn more about the cookies we use.
With the slider, you can enable or disable different types of cookies:
This website will:
Remember which cookies group you accepted
Essential: Remember your cookie permission setting
Essential: Allow session cookies
Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
Essential: Keep track of what you input in a shopping cart
Essential: Authenticate that you are logged into your user account
Essential: Remember language version you selected
This website won't:
Remember your login details
Functionality: Remember social media settings
Functionality: Remember selected region and country
Analytics: Keep track of your visited pages and interaction taken
Analytics: Keep track about your location and region based on your IP number
Analytics: Keep track of the time spent on each page
Analytics: Increase the data quality of the statistics functions
Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before. (Currently we do not use targeting or targeting cookies.
Advertising: Gather personally identifiable information such as name and location
This website will:
Remember which cookies group you accepted
Essential: Remember your cookie permission setting
Essential: Allow session cookies
Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
Essential: Keep track of what you input in a shopping cart
Essential: Authenticate that you are logged into your user account
Essential: Remember language version you selected
Functionality: Remember social media settings
Functionality: Remember selected region and country
This website won't:
Remember your login details
Analytics: Keep track of your visited pages and interaction taken
Analytics: Keep track about your location and region based on your IP number
Analytics: Keep track of the time spent on each page
Analytics: Increase the data quality of the statistics functions
Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before. (Currently we do not use targeting or targeting cookies.
Advertising: Gather personally identifiable information such as name and location
This website will:
Remember which cookies group you accepted
Essential: Remember your cookie permission setting
Essential: Allow session cookies
Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
Essential: Keep track of what you input in a shopping cart
Essential: Authenticate that you are logged into your user account
Essential: Remember language version you selected
Functionality: Remember social media settingsl Functionality: Remember selected region and country
Analytics: Keep track of your visited pages and interaction taken
Analytics: Keep track about your location and region based on your IP number
Analytics: Keep track of the time spent on each page
Analytics: Increase the data quality of the statistics functions
This website won't:
Remember your login details
Advertising: Use information for tailored advertising with third parties
Advertising: Allow you to connect to social sites
Advertising: Identify device you are using
Advertising: Gather personally identifiable information such as name and location
This website will:
Remember which cookies group you accepted
Essential: Remember your cookie permission setting
Essential: Allow session cookies
Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
Essential: Keep track of what you input in a shopping cart
Essential: Authenticate that you are logged into your user account
Essential: Remember language version you selected
Functionality: Remember social media settingsl Functionality: Remember selected region and country
Analytics: Keep track of your visited pages and interaction taken
Analytics: Keep track about your location and region based on your IP number
Analytics: Keep track of the time spent on each page
Analytics: Increase the data quality of the statistics functions
Advertising: Use information for tailored advertising with third parties
Advertising: Allow you to connect to social sitesl Advertising: Identify device you are using
Advertising: Gather personally identifiable information such as name and location